解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All g...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv009
更新日期:2015-05-01 00:00:00
abstract::The purpose of this study was to analyze the dosimetry and investigate the clinical outcomes of radiation-induced rib fractures (RIRFs) after stereotactic body radiotherapy (SBRT). A total of 126 patients with Stage I primary lung cancer treated with SBRT, who had undergone follow-up computed tomography (CT) at least ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru107
更新日期:2015-03-01 00:00:00
abstract::This retrospective analysis focusses on the impact of therapy on perceived long-term post-cancer treatment function. A validated questionnaire including items and components for the assessment of communicative ability, quality of voice and swallowing was sent to 129 patients. All patients were treated between 1998 and...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru093
更新日期:2015-01-01 00:00:00
abstract::Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of the reactions were g...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru079
更新日期:2015-01-01 00:00:00
abstract::It has previously been demonstrated that the presence of fetal bovine serum is necessary for TGF-β3 (transforming growth factor beta 3)-dependent elimination of low-dose hyper-radiosensitivity (HRS) in cells by 1 h of low-dose-rate γ-irradiation (0.2-0.3 Gy/h). The purpose of the present study was to identify the seru...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru053
更新日期:2014-11-01 00:00:00
abstract::The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBC...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru044
更新日期:2014-09-01 00:00:00
abstract::We evaluated toxicity and outcomes for patients with peripheral lung tumors treated with stereotactic body radiation therapy (SBRT) in a dose-escalation and dose-convergence study. A total of 15 patients were enrolled. SBRT was performed with 60 Gy in 5 fractions (fr.) prescribed to the 60% isodose line of maximum dos...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru037
更新日期:2014-09-01 00:00:00
abstract::Several studies have reported the usefulness of the field-in-field (FIF) technique in breast radiotherapy. However, the methods for the FIF technique used in these studies vary. These methods were classified into three categories. We simulated a radiotherapy plan with each method and analyzed the outcomes. In the firs...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt233
更新日期:2014-07-01 00:00:00
abstract::The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru012
更新日期:2014-07-01 00:00:00
abstract::Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the repair of DNA double-strand breaks generated by ionizing...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrt227
更新日期:2014-07-01 00:00:00
abstract::Radiation therapy (RT) has become particularly important recently for treatment of liver tumors, but there are few experimental investigations pertaining to radiation-induced liver injuries over long-term follow-up periods. Thus, the present study examined pathological liver features over a 10-month period using an in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru005
更新日期:2014-07-01 00:00:00
abstract::Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This st...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt140
更新日期:2014-05-01 00:00:00
abstract::In Japan, the use of adjuvant radiotherapy after prostatectomy for prostate cancer has not increased compared with the use of salvage radiotherapy. We retrospectively evaluated the outcome of adjuvant radiotherapy together with prognostic factors of outcome in Japan. Between 2005 and 2007, a total of 87 patients were ...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrt137
更新日期:2014-05-01 00:00:00
abstract::The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt118
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt112
更新日期:2014-03-01 00:00:00
abstract::The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt108
更新日期:2014-03-01 00:00:00
abstract::The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrt111
更新日期:2014-01-01 00:00:00
abstract::The aim of this study is to demonstrate the feasibility of estimating the strength of the moving radiation source during patient implantation. The requirement for the counting time was investigated by comparing the results of the measurements for the static source with those for the source moving at 2, 5, 10 and 20 cm...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt087
更新日期:2014-01-01 00:00:00
abstract::We investigated the effects of proton irradiation on the function and structure of the Pseudomonas aeruginosa peroxiredoxin (PaPrx). Polyacrylamide gel demonstrated that PaPrx proteins exposed to proton irradiation at several doses exhibited simultaneous formation of high molecular weight (HMW) complexes and fragmenta...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt081
更新日期:2014-01-01 00:00:00
abstract::To assess the mutational effects of radiation on vigorously proliferating plant tissue, the mutation spectrum was analyzed with Arabidopsis seedlings using the plasmid-rescue method. Transgenic plants containing the Escherichia coli rpsL gene were irradiated with γ-rays and carbon ion beams (320-MeV (12)C(6+)), and mu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt074
更新日期:2013-11-01 00:00:00
abstract::Before the sorafenib era, advanced but liver-confined hepatocellular carcinoma (HCC) was treated by liver-directed therapy. Hepatic arterial concurrent chemoradiotherapy (CCRT) has been performed in our group, giving substantial local control but frequent failure. The aim of this study was to analyze patterns of failu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt034
更新日期:2013-11-01 00:00:00
abstract::The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt073
更新日期:2013-11-01 00:00:00
abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt061
更新日期:2013-11-01 00:00:00
abstract::Since December 2009, after breast-conserving surgery for Stage 0-I cancer of the left breast, 21 women with relatively pendulous breasts underwent computed tomography prone and supine simulations. The adjuvant radiotherapy was 50 Gy in 25 fractions to the left breast alone. Four plans--conventional wedged tangents and...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章
doi:10.1093/jrr/rrt019
更新日期:2013-09-01 00:00:00
abstract::To understand the biological response of normal cells to fractionated carbon beam irradiation, the effects of potentially lethal damage repair (PLDR) and sublethal damage repair (SLDR) were both taken into account in a linear-quadratic (LQ) model. The model was verified by the results of a fractionated cell survival e...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt012
更新日期:2013-09-01 00:00:00
abstract::The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the pr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt032
更新日期:2013-09-01 00:00:00
abstract::miR-34a is transcriptionally induced by the tumor suppressor gene p53, which is often downregulated in non-small cell lung cancer (NSCLC). To address whether the downstream signal of miR-34a is sufficient to induce apoptosis and to alter cellular radiosensitivity, a chemical synthetic miR-34a mimic was delivered into ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs136
更新日期:2013-07-01 00:00:00
abstract::A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt041
更新日期:2013-07-01 00:00:00
abstract::The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt038
更新日期:2013-07-01 00:00:00
abstract::Differentiation-induction therapy is an attractive approach in leukemia treatment. It has been suggested that the accumulation of intracellular reactive oxygen species (ROS) is involved in megakaryocytic differentiation induced by phorbol 12-myristate 13-acetate (PMA) in the K562 leukemia cell line. Therefore, a ROS-i...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs125
更新日期:2013-05-01 00:00:00
abstract::The purpose of this study was to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for the treatment of N2-3 nasopharyngeal cancer (NPC) in Asian countries, especially regions of South and Southeast Asian countries where NPC is endemic. Between 20...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/jrr/rrs115
更新日期:2013-05-01 00:00:00
abstract::The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs084
更新日期:2013-03-01 00:00:00
abstract::A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs098
更新日期:2013-03-01 00:00:00
abstract::We propose a clinical workflow of stereotactic volumetric modulated arc therapy (VMAT) for a lung tumor from planning to tumor position verification using 4D planning computed tomography (CT) and 4D cone-beam CT (CBCT). A 4D CT scanner, an Anzai belt and a BodyFix were employed to obtain 10-phase respiratory-correlate...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs058
更新日期:2013-01-01 00:00:00
abstract::This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs050
更新日期:2012-11-01 00:00:00
abstract::We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment respons...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs021
更新日期:2012-09-01 00:00:00
abstract::External beam radiotherapy is a potential salvage or adjuvant therapy after radical prostatectomy (RP). The purpose of this study was to investigate the treatment outcome of salvage radiotherapy (RT) following RP for clinically localized prostate cancer and to identify factors that may predict the outcome of salvage R...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs034
更新日期:2012-09-01 00:00:00
abstract::Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs014
更新日期:2012-07-01 00:00:00
abstract::We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acq...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs013
更新日期:2012-07-01 00:00:00
abstract::To improve treatment conformity for prostate cancer, we investigated daily applicator displacement during high-dose-rate interstitial brachytherapy (HDR-ISBT). Thirty patients treated with HDR-ISBT as monotherapy were examined. All patients received a treatment dosage of 49 Gy per 7 fractions over 4 days. For dose adm...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00